Profilin for processivity
نویسندگان
چکیده
منابع مشابه
Profilin for processivity
SNX1 chooses its home via two membrane-binding domains. One targeting domain is the PX domain, which is known to bind to the endosomal phosphoinositide, PI3P. The second is a BAR domain, which was shown to target a fly protein to highly curved membranes and tubulate them. Cullen’s group shows that these domains combine to put mammalian SNX1 on the tubular portion of early endosomes (which also ...
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What is processivity? A protein is said to be processive if it catalyzes numerous catalytic turnover events while remaining with its substrate. Most single-subunit DNA polymerases only stay on DNA for a few nucleotide additions but, with the help of processivity factors, they can stay there for thousands of nucleotide addition steps. Processivity is especially important for the replication of l...
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Conventional kinesin is a highly processive motor that can take Ͼ 100 steps along a microtubule before dissociating. Various lines of evidence have led to a model of hand over hand processive motion, in which the trailing head detaches and rebinds to the next open tubulin dimer site on the same protofilament, leading to an 8-nm movement of supports the hand over hand mechanism. Processivity is ...
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The protein family of kinesins contains processive motor proteins that move stepwise along microtubules. This mechanism requires the precise coupling of the catalytic steps in the two heads, and their precise mechanical coordination. Here we show that these functionalities can be uncoupled in chimera of processive and non-processive kinesins. A chimera with the motor domain of Kinesin-1 and the...
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We propose a two-dimensional model for a complete description of the dynamics of molecular motors, including both the processive movement along track filaments and the dissociation from the filaments. The theoretical results on the distributions of the run length and dwell time at a given ATP concentration, the dependences of mean run length, mean dwell time and mean velocity on ATP concentrati...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1674rr5